Nicotinamide Riboside Supplementation In Progressive Multiple Sclerosis

This study is testing whether nicotinamide riboside (a form of vitamin B3 that the body converts into an energy-boosting molecule called NAD+) can slow disability progression in people with progressive multiple sclerosis (MS). **You may be eligible if...** - You are between 18 and 65 years old - You have been diagnosed with progressive MS (either secondary or primary progressive type) - Your disability level falls in a moderate range (EDSS score 3–6.5) - You have documented evidence of worsening disability over the past 24 months - You are able to walk (with or without aid) for a standard 25-foot walking test **You may NOT be eligible if...** - You have relapsing (not progressive) MS - You have an active cancer diagnosis or personal history of melanoma or breast cancer - You are pregnant or breastfeeding - You have dementia or another neurodegenerative disease - You have taken high-dose vitamin B3 supplements within 30 days of enrolling - You have a confirmed mitochondrial or metabolic genetic disorder Talk to your doctor to see if this trial is right for you.