RecruitingNCT07140367

"Transarterial Microembolization (TAME) in Inflammatory Knee Pathology"

"Transarterial Microembolization (TAME) in Inflammatory Knee Pathology: Prospective Observational Study."

Sponsor

Istituto Ortopedico Rizzoli

Enrollment

43 participants

Start Date

Sep 1, 2025

Study Type

OBSERVATIONAL

Conditions

Knee Osteoarthristis Inflammatory Articular Diseases

Summary

Patients with knee OA and chronic pain refractory to at least 3 months of conventional conservative therapy will be included in the study, which will evaluate the clinical results obtained after treatment with selective arterial embolization (selection and enrollment, treatment with selective arterial embolization, follow-up checks). Forty-three patients will be included in the study and will undergo the transarterial microembolization procedure after signing the informed consent form for participation in the study and the collection of anamnestic data. Subsequently, patients will be followed up with clinical evaluation at 1, 3, 6, 12, and 24 months of follow-up or until possible dropout for other treatment.

Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This observational study evaluates a minimally invasive procedure called transarterial microembolization (TAME) — where tiny particles are injected into small arteries feeding the knee to reduce inflammation and pain — in patients with chronic knee osteoarthritis who have not responded to conventional treatments. The study follows 43 patients over up to 24 months to assess how much pain relief and functional improvement they experience after the procedure. Adults over age 40 with moderate knee osteoarthritis (grade 2–3), pain at rest or at night, and at least 3 months of failed conservative therapy (such as medications, injections, or physical therapy) may be eligible. Participation involves the one-time procedure and follow-up clinical evaluations at 1, 3, 6, 12, and 24 months. This summary was generated by AI to help patients understand the study in plain language.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURETransarterial Microembolization

Identification of the hypervascularization of the knee. Selective and super-selective catheterization of pathological genicular arterial branches, through the use of micro-catheters. - Injection of embolizing material (Nexsphere-F - Kardia) - Control of technical success: the embolization will be followed by diagnostic arteriography that will evaluate the success of the procedure (occlusion of more than 90 percent of the pathologic vasculature).

Locations(1)

IRCCS Istituto Ortopedico Rizzoli

Bologna, Bologna, Italy

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