RecruitingPhase 2NCT07143734

Transcranial Pulse Stimulation for Alzheimer's Disease

A Pilot Randomized Placebo-Controlled Trial of Transcranial Pulse Stimulation (TPS) in Early Alzheimer's Disease (AD) Subjects


Sponsor

Chinese University of Hong Kong

Enrollment

40 participants

Start Date

Jul 21, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

TPS is a non-invasive therapeutic modality that uses focused, low-energy pulse stimulation to stimulate tissue regeneration and reduce inflammation. In the context of neurological disorders, it is hypothesized that TPS can modulate neuronal activity, enhance synaptic plasticity, and reduce neuroinflammation. It is a relatively new application in neurological disease treatment and is still under intense investigation.


Eligibility

Min Age: 60 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a non-invasive brain stimulation technique called Transcranial Pulse Stimulation (TPS) — which uses brief ultrasound pulses aimed at the brain — to see if it can improve memory and thinking in people with early-stage Alzheimer's disease. **You may be eligible if...** - You are between 60 and 90 years old - You have been clinically diagnosed with Alzheimer's disease at an early stage - A geriatrician has confirmed you have the mental capacity to agree to participate - You have a family caregiver who can assist and answer questionnaires **You may NOT be eligible if...** - You cannot understand Chinese (the study is conducted in Chinese) - You are unable to provide informed consent - You cannot remain still for 30 minutes - You have a brain tumor, brain aneurysm, metal implants in the brain, blood clotting disorders, or a history of blood clots - You have significant alcohol or substance dependence Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEtranscranial pulse stimulation (TPS)

The TPS/Sham-TPS therapy is administered for the first two weeks, followed by additional sessions at some week intervals.

DEVICEtranscranial pulse stimulation (TPS-Sham)

Participants will undergo an identical procedure using a device that mimics the sound and sensation of active TPS but delivers no therapeutic energy pulses to the brain.


Locations(1)

Department of Medicine & Therapeutics, Faculty of Medicine, The Chinese UNiversity of Hong Kong

Hong Kong, Hong Kong

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NCT07143734


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