Inflammatory Biomarkers as Predictors of PONV Following Pediatric Orchiopexy
Association of Preoperative Inflammatory Biomarkers With Postoperative Nausea and Vomiting in Children Undergoing Orchiopexy
Diskapi Yildirim Beyazit Education and Research Hospital
170 participants
Sep 8, 2025
OBSERVATIONAL
Conditions
Summary
Orchiopexy is a common surgical procedure for the treatment of cryptorchidism in the pediatric population, with a high incidence of postoperative nausea and vomiting (PONV). Recent evidence suggests that systemic inflammation may contribute to PONV pathogenesis, and preoperative inflammatory biomarkers such as NLR, PLR, SII, MLR, and SIRI could serve as predictive indicators. This prospective observational study aims to evaluate the relationship between these biomarkers and PONV incidence in children undergoing orchiopexy.
Eligibility
Inclusion Criteria4
- Patients aged between 1 and 8 years
- Patients with ASA physical status I-II
- Patients scheduled for elective orchiopexy
- Obtained written informed consent from parents/guardians
Exclusion Criteria4
- Patients younger than 1 year or older than 8 years
- Patients with ASA physical status III or higher
- Presence of acute infection signs
- History of previous nausea or vomiting
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Interventions
Blood samples will be collected preoperatively to measure inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index, monocyte-to-lymphocyte ratio (MLR), and systemic inflammation response index. These values will be analysed in relation to the incidence of postoperative nausea and vomiting within the first 6 hours after pediatric orchiopexy. No experimental drug or device will be administered as part of the study; all procedures will be conducted within the scope of standard perioperative care.
Locations(1)
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NCT07148063