RecruitingNCT07151768

Prospective Validation of the Novel PVD-B65 Risk Score in Patients With Chronic Lung Disease and Pulmonary Hypertension


Sponsor

Temple University

Enrollment

100 participants

Start Date

Sep 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

Prospective observational study to determine if the PVD-B65 risk score for one-year mortality in patients with chronic lung disease and pulmonary hypertension (CLD-PH) can accurately risk stratify these patients and successfully predict one-year mortality from time of pulmonary hypertension diagnosis. PVD-B65 risk score was developed in a retrospective cohort of patients with CLD-PH, utilizing the presence of pulmonary fibrosis without emphysema, pulmonary vascular resistance (PVR) \> 5 woods units (WU), 6-minute walk distance (6MWD) \< 150 meters, B-natriuretic type peptide (BNP) \> 200 pg/mL or N-terminal pro-natriuretic type peptide (NT-proBNP) \> 300 pg/dL, and age \> 65 years as the score components.


Eligibility

Min Age: 18 YearsMax Age: 99 Years

Plain Language Summary

Simplified for easier understanding

This study is validating a new risk-scoring tool called PVD-B65 for predicting outcomes in patients who have both chronic lung disease and high blood pressure in the lungs (pulmonary hypertension). Researchers want to confirm whether this score helps predict how patients will do over time. **You may be eligible if...** - You are 18 or older - You have been diagnosed with a chronic lung disease such as COPD, pulmonary fibrosis, ILD, or advanced sarcoidosis - You have been confirmed to have pre-capillary pulmonary hypertension through a right-heart catheterization procedure - You are able to attend follow-up visits and complete walking/exercise tests **You may NOT be eligible if...** - You have pulmonary hypertension that is NOT related to lung disease (e.g., idiopathic pulmonary arterial hypertension or clot-related pulmonary hypertension) - You have a severe uncontrolled illness that affects life expectancy - You have had a lung or heart transplant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTObservational Study

* assignment of PVD-B65 score derived from standard of care testing * no therapeutic intervention or other treatment


Locations(1)

Temple University Hospital

Philadelphia, Pennsylvania, United States

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NCT07151768


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