Investigation of the Effects of Renal Impairment on the Pharmacokinetics, Safety, and Tolerability of Opemalirsen (AZD2373)

This study is examining how kidney function affects the way the body processes a drug called opemalirsen (AZD2373). Participants with varying degrees of kidney impairment will be compared to healthy volunteers to understand if kidney disease changes how the drug behaves. **You may be eligible if...** - You are between 18 and 80 years old - You are either a healthy volunteer with normal kidney function, OR you have stable chronic kidney disease not requiring dialysis - Your body weight is at least 50 kg and your BMI is between 18 and 40 - You are willing to use appropriate contraception **You may NOT be eligible if...** - You have liver disease, cirrhosis, or a history of hepatitis B or C - You have HIV - You have a history of drug or alcohol abuse in the past year - Your kidney function is rapidly declining - You have had a kidney transplant - You have had major surgery within the past 30 days - You have abnormal heart rhythm (prolonged QT interval) - You have been in another drug study within the past 30 days Talk to your doctor to see if this trial is right for you.