RecruitingNCT07156370

Salivary Cortisol and Hypercortisolism in Type 2 Diabetes

Study to Explore the Prevalence of Hypercortisolism in Patients With Type 2 Diabetes and Assess the Correlation Between Salivary Cortisol and Glucose Levels


Sponsor

Shanghai 6th People's Hospital

Enrollment

500 participants

Start Date

Sep 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to explore the prevalence of hypercortisolism in a population with difficult to control type 2 diabetes despite receiving standard-of-care therapies. Additionally, the study will evaluate the correlation between salivary cortisol levels and glycemic control.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study explores whether elevated cortisol (a stress hormone) contributes to poorly controlled Type 2 diabetes. Researchers will measure cortisol levels through saliva and a wearable patch to see if hidden cortisol excess might be making blood sugar harder to manage. **You may be eligible if...** - You are between 18 and 80 years old - You have Type 2 diabetes that is difficult to control (high HbA1c despite multiple medications) - You are taking 3 or more diabetes medications, or insulin plus other drugs, or have complications/high blood pressure requiring multiple medications **You may NOT be eligible if...** - You have Type 1 diabetes or newly diagnosed diabetes (less than 1 year) - You have used systemic steroid medications (like prednisone) in the past 3 months - You are pregnant or breastfeeding - You have severe heart, liver, or kidney problems - You had a serious diabetes emergency (like ketoacidosis) in the past 3 months - You have already been diagnosed with Cushing's syndrome Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Shanghai Sixth People's Hospital

Shanghai, China

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NCT07156370


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