Urolithin A in Patients With Previously Untreated Solid Tumors Receiving Immune Checkpoint Inhibitors

This study tests whether a natural supplement called Urolithin A — found in foods like pomegranates and berries — can help boost the effectiveness of immunotherapy (cancer treatments that use the immune system) in people newly diagnosed with solid tumors. **You may be eligible if...** - You are 18 or older - You have been newly diagnosed with a solid cancer and have not yet received any systemic treatment - Your doctor has planned immunotherapy (with or without chemotherapy) as your first treatment - You are in reasonably good physical health (able to carry out daily activities) - Your life expectancy is at least 3 months - You are willing and able to attend all study visits **You may NOT be eligible if...** - You have already received cancer treatment - You are pregnant or breastfeeding - You have serious health conditions that would prevent participation Talk to your doctor to see if this trial is right for you.