RecruitingNCT07161869

Preoperative Evaluation of Lymph Nodes of Cholangiocarcinoma (POELH-III)

Preoperative Evaluation of Lymph Nodes of Cholangiocarcinoma by Endoscopic Ultrasound (POELH-III)

Sponsor

Erasmus Medical Center

Enrollment

250 participants

Start Date

Feb 5, 2026

Study Type

OBSERVATIONAL

Conditions

Cholangiocarcinoma Intrahepatic Cholangiocarcinoma (Icc)Hilar Cholangiocarcinoma Adenocarcinoma of Biliary Tract Perihilar Cholangiocarcinoma Common Bile Duct Neoplasms

Summary

In the POELH-II trial (Clinicaltrials.gov ID NCT05678218) patients with presumed resectable perihilar (pCCA), intrahepatic (iCCA) or mid-common bile duct (CBD) cholangiocarcinoma had the outcomes of their preoperative endoscopic ultrasound (EUS) registered. This EUS procedure was done systematically, targeting lymph nodes (LNs) with the aim to identify LN metastases preoperatively. The goal of this follow-up observational cohort study (POELH-III) is to assess the yield of preoperative EUS, with an improved EUS approach. The EUS protocol as used in the POELH-II trial was improved based on preliminary results of the POELH-II trial. The main questions it aims to answer is: \- The number of patients precluded from surgical work-up due to positive regional or extraregional LNs identified by EUS guided tissue acquisition

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a procedure called Registration of all findings during preoperative Endoscopic Ultrasound for people with adenocarcinoma of biliary tract, cholangiocarcinoma, and other related conditions. The study is currently recruiting participants at 6 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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