Postural Mobilization Compared to Noradrenaline Only in Off-Pump CABG Surgery
Comparison of Hemodynamic Management by Postural Mobilization Versus Chemical Vasoconstriction Using Noradrenaline Exclusively in Off-pump Coronary Artery Bypass Graft Surgery: A Prospective, Randomized, Comparative, Single-center Study.
Infirmerie Protestante de Lyon
50 participants
Oct 6, 2025
INTERVENTIONAL
Conditions
Summary
This interventional prospective randomized study is designed to compare hemodynamic management using postural mobilization (+/- noradrenaline) versus noradrenaline only in patients undergoing open-heart coronary artery bypass graft (CABG) surgery.
Eligibility
Inclusion Criteria8
- Adult patient
- patient requiring isolated coronary bypass surgery
- Elective procedure or medical emergency
- First cardiac surgery
- Patient with an EF ≥30%
- Mandatory affiliation to a social security system
- Signed informed consent form
- Suspension of renin-angiotensin system inhibitors and angiontensn-neprilysin receptor blockers and sartans the day before surgical procedure
Exclusion Criteria10
- Contraindication to an inotropic substance (only NA will be used)
- Contraindication to passive leg raising
- Patient in a life-threatening emergency
- History of cardiac surgery
- Bilateral iliac or common femoral artery occlusion
- EF < 30%
- Pregnancy and breastfeeding
- Renal failure (GFR < 40 ml/min/1.73 m²)
- Patient with bilateral thigh amputation
- Class III obesity BMI > 40 kg/m²
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Interventions
Passive leg raising will be used in the experimental group in order to manage hemodynamics: legs will be raised to an angle of approx. 45°
Noradrenaline will be used for hemodynamic management. Passive leg raising will not be used in this group
Locations(1)
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NCT07163858