Identifying Genetic Targets in Gynecological Tumors
Identification of Genetic Targets in Gynecological Tumors Via a Triple in Silico Ex-vivo / in Vivo Approach
Azienda USL Reggio Emilia - IRCCS
180 participants
Nov 17, 2021
OBSERVATIONAL
Conditions
Summary
This observational study aims to identfy genetic targets involved in the pathogenesis of gynecological tumors, with a focus on high-grade serous ovarian carcinoma. Using a triple approach - in silico, ex vivo and in vitro - the study will investigate the role of gonadotropins and their related signaling pathways in the epithelial ovarian cancers. Gene and protein expression levels will be evaluated through transcriptomic analysis, immunohistochemistry and functional assays on tumor cell lines. The goal is to uncover potential diagnostic or therapeutic targets in gynecological malignancies.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
RNA extraction and gene expression
Locations(1)
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NCT07169396