CEA-Targeted CAR-T Therapy in CEA-Positive Advanced Solid Tumors

This study is testing a new type of immune cell therapy called CAR-T, which uses your own immune cells that are re-engineered to target a protein called CEA found on certain cancer cells. It is aimed at people with advanced solid tumors such as colorectal, stomach, esophageal, pancreatic, lung, or bile duct cancer that have not responded to standard treatments. **You may be eligible if...** - You are 18 or older - You have been diagnosed with advanced or metastatic cancer of the colon, stomach, esophagus, pancreas, lungs, or bile ducts - Your cancer has not responded to at least two prior lines of treatment - Your tumor tests positive for the CEA protein - You have at least one measurable area of cancer on imaging **You may NOT be eligible if...** - Your cancer does not test positive for CEA - You have active brain metastases or serious infections - You have severe heart, liver, or kidney problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.