Menstrual Cycle TMS Plasticity Pilot
Pilot Study on Menstrual Cycle-Related Hormonal Effects on Motor Cortex Plasticity Assessed by TMS in Healthy Young Adults
University of Pennsylvania
100 participants
Dec 15, 2025
OBSERVATIONAL
Conditions
Summary
Aim 1: Assess how menstrual cycle phase affects motor cortex plasticity in females. Aim 2: Compare motor cortex plasticity between males and females across the same time points, identifying potential sex differences in TMS response. Aim 3: Examine associations between serum hormone levels and TMS-induced plasticity within and between sexes.
Eligibility
Inclusion Criteria2
- Able to give their consent
- If female, must have menstrual cycles of normal frequency, regularity, and duration.
Exclusion Criteria5
- Non-English speaking
- Any medical condition that increases risk for TMS
- History of seizure
- History of epilepsy
- Increased risk of seizure for any reason
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Interventions
Subjects will receive a series of 60 10s trains that will be presented over the course of the \~3.5 min session. Each train will consist of 2 s of stimulation with an 8 s ITI. During the 2 s of stimulation, 10, 50 Hz bursts will be repeated at intervals of 200 ms (5 Hz). iTBS will be administered at 100% of the motor threshold (MT).
Locations(1)
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NCT07180654