Feasibility, Safety, and Preliminary Clinical Efficacy of Magnetic Resonance Imaging-guided Repetitive Transcranial Magnetic Stimulation (rTMS) in Adolescents With Depression: A Randomized, Double-Blind, Controlled Pilot Study

This study is testing whether a brain stimulation technique called repetitive Transcranial Magnetic Stimulation (rTMS) — guided by MRI imaging to target the right brain areas — can help teenagers aged 12–18 with depression that hasn't improved with medication. **You may be eligible if...** - You are 12–18 years old with a current diagnosis of major depressive disorder - You have been on stable psychiatric medication for at least 4 weeks - Your depression scores on a standard scale are at or above a set threshold **You may NOT be eligible if...** - You have other psychiatric conditions besides anxiety disorders - You have symptoms of psychosis, mania, or a history of seizures or neurological disease - You have previously received brain stimulation therapy (TMS, ECT, or similar) - You have a history of alcohol or substance abuse - You are pregnant or breastfeeding - You have a high current suicide risk Talk to your doctor to see if this trial is right for you.