RecruitingNot ApplicableNCT06878859

Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use

AMP-C: A Digital Therapeutic for Reward Dysfunction in Co-Occurring Depression and Cannabis Use


Sponsor

Massachusetts General Hospital

Enrollment

80 participants

Start Date

Feb 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a digital intervention for co-occurring cannabis use and depression. Participants will be randomized to complete Amplification of Positivity - Cannabis Use (AMP-C) or symptom tracking. The main outcomes will include changes in depressive symptoms and cannabis use, as well as usability ratings.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests a digital (app or online) mental health program designed to treat both depression and problematic cannabis use at the same time. Many people use cannabis to cope with depression, which can make both conditions harder to treat — this program aims to address both together. **You may be eligible if:** - You are 18 or older and live in the United States - You read and understand English - You have moderate symptoms of depression (as measured by a standard questionnaire) - You use cannabis in a way that causes problems in your life - You have access to a smartphone or computer **You may NOT be eligible if:** - You live outside the United States - Your depression is very severe and requires immediate clinical care - You are not interested in reducing your cannabis use - You have a condition that would make participating in a digital program unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

BEHAVIORALAmplification of Positivity - Cannabis Use (AMP-C)

AMP-C is a smartphone-based digital intervention that includes activities that focus on positivity (e.g., noticing and capitalizing on positive events) to increase positive emotions, thoughts, and behaviors. The role and impact of CU on the maintenance of depression and reward dysfunction (and vice versa), is intertwined throughout the intervention.


Locations(1)

Massachusetts General Hospital

Boston, Massachusetts, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06878859


Related Trials