Prilocaine for Sphenopalatine Ganglion Block in Endoscopic Hypophysectomy
Bilateral Sphenopalatine Ganglion Block Using Prilocaine Versus Lidocaine as Adjuvants to General Anesthesia During Endoscopic Hypophysectomy, Randomized Trial.
Kasr El Aini Hospital
54 participants
Dec 1, 2025
INTERVENTIONAL
Conditions
Summary
Patients undergoing endoscopic surgeries for pituitary adenoma excision suffer from wide swings in blood pressure that might increase bleeding and interfere with the surgical field. Local anethetic infiltration and regional nerve blocks have been used to provide better analgesia, control blood pressure and improve surgical field. Limited studies evaluated shenopalatine ganglion block in pituitary adenoma excision with promising outcomes. The proposed study will compare the efficacy of two local anesthetics, prilocaine and lidocaine, for spenopalatine ganglion block in patients undergoing endoscopic pituitary adenoma excision. Evaluating the control of the intraoperative blood pressure and analgesic sparing are the main objectives of the proposed study.
Eligibility
Inclusion Criteria4
- Patients with pituitary adenoma undergoing endoscopic hypophysectomy.
- ASA physical status I and II.
- Age above 21, below 45 years.
- Male or female
Exclusion Criteria10
- Any patient below 21 years or above 45 years.
- Patients suffering from any of the following conditions:
- Disturbed conscious level.
- Coagulation abnormalities.
- Poorly controlled blood pressure and/or heart rate.
- Increased intracranial tension.
- Liver and kidney disorders.
- Patients on anticoagulants and/or NSAIDS (non-steroidal anti- inflammatory drugs
- Patients addicted to drugs and/or alcohol.
- Patients with disturbed conscious level at the end of the surgery, GCS >14
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Interventions
Sphenopalatine ganlion block with 2ml of 2% lidocaine and 0.5ml of diluted adrenaline after general anesthesia in patients undergoing enoscopic hypophysectomy.
Sphenopalatine ganlion block with will receive 2ml of 4% prilocaine and 0.5ml saline after general anesthesia in patients undergoing enoscopic hypophysectomy.
Sphenopalatine ganlion block with will receive 2ml of 4% prilocaine in addition to 0.5ml of diluted adrenaline. after general anesthesia in patients undergoing enoscopic hypophysectomy.
Locations(1)
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NCT07188987