RecruitingNot ApplicableNCT07208669

Evaluating Whether Treating Elevated Blood Pressure in the Inpatient Setting Impacts Patient Outcomes

Evaluating Whether Treating Elevated Blood Pressure in the Inpatient Setting Impacts Patient Outcomes: the ACT-BP Pilot


Sponsor

Elizabeth Pfoh

Enrollment

4 participants

Start Date

Nov 11, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The vast majority of the 36.2 million individuals admitted to U.S. hospitals are diagnosed with hypertension and experience an elevated blood pressure (BP) reading during hospitalization. There are no guidelines for managing asymptomatically elevated BPs in the inpatient setting, and growing observational evidence suggests that antihypertensive medication intensification increases harm. The proposed study tests whether a unit-based intervention (ACT-BP) can reduce antihypertensive medication intensification and provides information that is scientifically necessary for designing a cluster-randomized clinical trial that identifies the impact of intensification after experiencing an asymptomatically elevated BP on patient outcomes.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study examines whether routinely treating high blood pressure in hospitalized patients (who are admitted for other reasons) actually improves their health outcomes — or whether it might cause unnecessary side effects. **You may be eligible if...** - You are 18 or older - You are admitted to a standard medical hospital unit (not intensive care) - Your blood pressure is elevated (systolic above 160 mmHg) during your hospital stay **You may NOT be eligible if...** - You are under 18 - You are experiencing a hypertensive emergency or cardiac symptoms right now - You have had a recent stroke, heart attack, or acute heart failure - You have end-stage kidney disease or are on dialysis - You have been in the hospital for more than 10 days - You were recently in the ICU - You are pregnant or recently gave birth - You are being discharged within 24 hours of admission Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERACT-BP Intervention

In our intervention units, the study team will change the unit-based protocols to follow the ACT-BP intervention. First, it prompts the nurse to identify if a patient is experiencing hypertensive emergencies or cardiac symptoms. If so, it suggests calling the physician. If not, it prompts assessment for pain, anxiety, nausea, or hunger and provides evidence-based suggestions. It also prompts monitoring to enhance patients' safety in the case of rapidly rising BP. This algorithm will provide a path for ensuring patients receive appropriate treatment.


Locations(2)

Cleveland Clinic Main Campus

Cleveland, Ohio, United States

Cleveland Clinic Hillcrest

Mayfield Heights, Ohio, United States

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NCT07208669


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