Saline Contrast Electrical Impedance Tomography Method for Diagnosis of Acute Pulmonary Embolism
A Multicenter Comparative Study of Saline Contrast Electrical Impedance Tomography Method Versus CTPA in the Diagnosis of Acute Pulmonary Embolism
Peking Union Medical College Hospital
343 participants
Sep 24, 2025
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to compare the consistency of saline contrast Electrical Impedance Tomography(EIT) method and Computed Tomography Pulmonary Angiography (CTPA) in diagnosing acute pulmonary embolism. The main question it aims to answer is: Can bedside saline contrast EIT method be used for the diagnosis of acute pulmonary embolism? The participants will undergo saline contrast EIT and CTPA examinations successively within 24 hours.
Eligibility
Inclusion Criteria5
- Patients with clinically suspected or confirmed acute pulmonary embolism (PE) presenting with acute respiratory failure;
- Availability of CTPA results within 24 hours or scheduled to undergo CTPA within the next 24 hours;
- Age >18 years; no gender restrictions;
- Presence of central venous access (internal jugular or subclavian vein) or peripheral forearm venous access;
- Willingness to participate with signed informed consent from either the patient or legal guardian.
Exclusion Criteria6
- Pregnancy or lactation;
- Relative contraindications to EIT examination (e.g., chest wall wounds at electrode belt placement site, presence of pacemakers);
- Severe hypernatremia (serum sodium >155 mmol/L);
- Inability to maintain expiratory breath-hold for ≥8 seconds;
- BMI >50 or severe thoracic deformities;
- Current extracorporeal membrane oxygenation (ECMO) therapy.
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Interventions
This study will enroll patients with clinically suspected or confirmed acute pulmonary embolism (PE) presenting with acute respiratory failure, who undergo electrical impedance tomography (EIT) with saline contrast within 24 hours before or after computed tomography pulmonary angiography (CTPA). The EIT procedure is performed as follows: 1. Breath-Hold Maneuver: (1)Spontaneous breathing patients: Supine position, instructed to hold expiration for ≥8 seconds. (2)Mechanically ventilated patients: Expiratory hold (\>8 sec) achieved via ventilator; deeper sedation will be applied when feasible to prolong breath-hold. 2. Venous Access: (1)Preferred: Central venous catheter (internal jugular or subclavian vein).(2)Alternative: Peripheral forearm vein (preferably the median cubital vein). 3. Contrast Administration:(1)Central venous route: 10 mL of 10% NaCl.(2)Peripheral venous route: 15 mL of 5% NaHCO₃.
Patients who meet the inclusion criteria will undergo CTPA examination using conventional clinical diagnostic methods.
Locations(1)
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NCT07190079