RecruitingNot ApplicableNCT07190560

Against Chikungunya Virus and Neonatal Infection


Sponsor

Centre Hospitalier Universitaire de la Réunion

Enrollment

60 participants

Start Date

Aug 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn if administration of plasma, from a whole blood donation from an individual who has declared a Chikungunya infection for less than 6 months , to a newborn, whose mother has a peripartum chikungunya infection, will have an impact on the proportion of newborns surviving without encephalitis/encephalopathy (EE) within the first 5 days of life. Researchers will compare results to an observational study of 30 newborns who couldn't have been proposed to participate at the clinical trial, because of delay of diagnosis or delay of transfer to hospital which doesn't allow transfusion or parents not accepting plasma transfusion to the newborn. Participants of the clinical trial will: * receive a transfusion, * visit the clinic and undergo biological tests every day until day 7 and once between 1 and 3 months. Participant of observational study as part of their regular medical care, and biological data will be reused for the research from the mother's diagnosis until the newborn reaches 3 months of age


Eligibility

Min Age: 0 DaysMax Age: 2 Days

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a biological treatment called plasma transfusion : PC-CHIK-V for people with chikungunya virus infection, encephalopathy, and other related conditions. The study is currently recruiting participants at 2 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALplasma transfusion : PC-CHIK-V

plasma transfusion , from donation from an individual who has declared a Chikungunya infection for less than 6 months , to a newborn, whose mother has a peripartum chikungunya infection


Locations(2)

CHU La Réunion

Saint-Pierre, France

Centre hospitalier de Mayotte

Mamoudzou, Mayotte

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NCT07190560


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