Encephalopathy Clinical Trials

115 recruitingLast updated: June 18, 2026

There are 115 actively recruiting encephalopathy clinical trials across 35 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1, Phase 4. Top locations include Boston, Massachusetts, United States, Philadelphia, Pennsylvania, United States, San Diego, California, United States. Updated daily from ClinicalTrials.gov.


Encephalopathy Trials at a Glance

115 actively recruiting trials for encephalopathy are listed on ClinicalTrialsFinder across 6 cities in 35 countries. The largest study group is Not Applicable with 27 trials, with the heaviest enrollment activity in Boston, Philadelphia, and San Diego. Lead sponsors running encephalopathy studies include Semmelweis University, Mayo Clinic, and University of Wisconsin, Madison.

Browse encephalopathy trials by phase

Treatments under study

About Encephalopathy Clinical Trials

Looking for clinical trials for Encephalopathy? There are currently 9 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Encephalopathy trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Encephalopathy clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 115 trials

Recruiting
Phase 2

A Dose Escalation Study of Levetiracetam in the Treatment of Neonatal Seizures

Neonatal EncephalopathyNeonatal SeizureSeizure Newborn+1 more
University of California, San Diego133 enrolled5 locationsNCT05610085
Recruiting
Phase 3

A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathies (DEE)

Developmental and Epileptic Encephalopathy
Longboard Pharmaceuticals320 enrolled114 locationsNCT06719141
Recruiting
Phase 2

Intravenous Brincidofovir as an Antiviral for Treatment of Progressive Multifocal Leukoencephalopathy: A Pilot Study

Progressive Multifocal Leukoencephalopathy
National Institute of Neurological Disorders and Stroke (NINDS)24 enrolled1 locationNCT07511049
Recruiting

Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)

Progressive Multifocal Leukoencephalopathy
National Institute of Neurological Disorders and Stroke (NINDS)700 enrolled1 locationNCT01730131
Recruiting
Phase 1

Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy

Multiple SclerosisProgressive Multifocal LeukoencephalopathyOther Neuroinflammatory Diseases With BBB Leakage
National Institute of Neurological Disorders and Stroke (NINDS)15 enrolled1 locationNCT05849467
Recruiting
Phase 3

A Clinical Trial of Elsunersen in Pediatric SCN2A-DEE to Assess Efficacy and Safety

Epileptic EncephalopathySCN2A Encephalopathy
Praxis Precision Medicines40 enrolled10 locationsNCT07019922
Recruiting
Phase 1Phase 2

A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy

Epileptic Encephalopathy
Institut de Recherches Internationales Servier20 enrolled16 locationsNCT07227857
Recruiting
Not Applicable

Study of Pathophysiology of Status Epilepticus and Dysimmune Encephalitis

Status EpilepticusDysimmune Encephalopathy
Assistance Publique - Hôpitaux de Paris400 enrolled1 locationNCT04421846
Recruiting

Healthy Little Eyes

Neonatal EncephalopathyEncephalopathyHypoxic-ischemic encephalopathy.
University of Wisconsin, Madison125 enrolled1 locationNCT05971446
Recruiting
Not Applicable

Neonate Cerebral Activity in Immediate Post Partum

Neonatal EncephalopathyAnoxia-Ischemia, Brain
Centre Hospitalier Universitaire, Amiens60 enrolled1 locationNCT04225975
Recruiting
Phase 2

TReatment for ImmUne Mediated PathopHysiology

acute liver injuryImmune DysregulationHepatic Encephalopathy+2 more
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)163 enrolled24 locationsNCT04862221
Recruiting

Long-term Prospective Study of Korean CADASIL Patients

CadasilCerebral Autosomal Dominant Arteriopatie With Subcortical Infarcts and Leukoencephalopathy
Jeju National University Hospital500 enrolled1 locationNCT07497867
Recruiting
Phase 3

A Clinical Trial for Participants With DEE to Assess Efficacy, Safety, Tolerability, and PK of Relutrigine

Developmental and Epileptic Encephalopathy 1
Praxis Precision Medicines160 enrolled11 locationsNCT07010471
Recruiting

Assessing Intellectual and Motor Outcomes in High-risk Infants

Motor impairmentCerebral PalsyCerebral Palsy (CP)+7 more
University College Cork600 enrolled4 locationsNCT06857539
Recruiting
Not Applicable

Against Chikungunya Virus and Neonatal Infection

TransfusionEncephalopathyNeonatal+1 more
Centre Hospitalier Universitaire de la Réunion60 enrolled2 locationsNCT07190560
Recruiting

Cool Prime Comparative Effectiveness Study for Mild HIE

Mild Hypoxic Ischemic Encephalopathy of Newborn
University of Texas Southwestern Medical Center460 enrolled1 locationNCT04621279
Recruiting

Predictive Value of aEEG and Cerebral Oxygenation on Neurological Outcomes in Newborns With Mild Hypoxic-Ischemic Encephalopathy

Hypoxic-Ischemic Encephalopathy Mild
Uludag University30 enrolled3 locationsNCT07393620
Recruiting

Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1)

TBITBI (Traumatic Brain Injury)Hemodynamic Instability+2 more
Children's Hospital Los Angeles1,000 enrolled1 locationNCT06195345
Recruiting
Phase 4

Hydrocortisone Therapy Optimization During Hypothermia Treatment in Asphyxiated Neonates

HypotensionAsphyxiaCirculatory Failure Neonatal+1 more
Semmelweis University50 enrolled1 locationNCT05836610
Recruiting
Not Applicable

Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy in Vietnam

Hypoxic-ischemic encephalopathy (HIE)
National Children's Hospital, Vietnam120 enrolled1 locationNCT07555652