How do Patients With Amnesia Acquire New Knowledge?
New Semantic Learning in Patients With Selective Brain Lesions in Temporal Regions: a Behavioural and MRI Study
University Hospital, Toulouse
150 participants
Apr 8, 2026
INTERVENTIONAL
Conditions
Summary
THE STUDY AIMS to constitute the largest group of patients with major memory impairment resulting from various etiology and specific lesions of the medial temporal lobe (MTL) and use a combined psychometric and neuroimaging approach to study the factors allowing these patients to successfully learn new semantic information.
Eligibility
Inclusion Criteria6
- Patients aged between 18 and 70 years
- Living in France since less than 20 years, being able to understand the French language, and have basic cultural knowledge as evaluated in classical clinical consultation
- Written agreement to participate in the study
- Intellectual capacities compatible with the cognitive tasks and signing of consent
- Affiliation to the French social security system
- For patients: bilateral brain lesion of the medial temporal lobe or the extended hippocampal system
Exclusion Criteria3
- Subjects under the age of 18 or over 70
- Contraindications for MRI (examples: wearers of a pacemaker or cardiac defibrillator, implanted equipment activated by an electrical, magnetic or mechanical system, wearers of haemostatic clips for intracerebral aneurysms or carotid arteries, wearers of orthopedic implants, claustrophobic)
- Refusal to be informed of an anomaly detected during the MRI
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Interventions
structural and functional resting state MRI
2 cognitive research tasks of semantic learning and neuropsychological assessment
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07191197