A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid Malignancies

This is an early-phase study testing a new experimental drug called ST-01156 in people with advanced solid tumors (cancers that have spread and cannot be surgically removed). The study aims to determine a safe dose and look for early signs of whether the drug is working. **You may be eligible if...** - You are 18 years or older (or 16+ with Ewing sarcoma) - You have a solid tumor that has spread or cannot be removed surgically - You have at least one measurable area of cancer - You are in reasonably good health (able to carry out daily activities) - Your liver, kidneys, and blood counts are functioning adequately **You may NOT be eligible if...** - You received radiation therapy within the past 2 weeks - You have active brain metastases that have not been treated - You have received prior treatment that overlaps with this drug's mechanism Talk to your doctor to see if this trial is right for you.