Ewing Sarcoma Clinical Trials

47 recruitingLast updated: June 17, 2026

There are 47 actively recruiting ewing sarcoma clinical trials across 31 countries. Studies span Phase 1, Phase 2, Not Applicable, Phase 3, Early Phase 1. Top locations include New York, New York, United States, Houston, Texas, United States, Los Angeles, California, United States. Updated daily from ClinicalTrials.gov.


Ewing Sarcoma Trials at a Glance

47 actively recruiting trials for ewing sarcoma are listed on ClinicalTrialsFinder across 6 cities in 31 countries. The largest study group is Phase 1 with 24 trials, with the heaviest enrollment activity in New York, Houston, and Los Angeles. Lead sponsors running ewing sarcoma studies include Milton S. Hershey Medical Center, Istituto Ortopedico Rizzoli, and St. Jude Children's Research Hospital.

Browse ewing sarcoma trials by phase

Treatments under study

About Ewing Sarcoma Clinical Trials

Looking for clinical trials for Ewing Sarcoma? There are currently 41 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Ewing Sarcoma trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Ewing Sarcoma clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 47 trials

Recruiting
Phase 1Phase 2

Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

OsteosarcomaEwing SarcomaNeuroblastoma+4 more
Milton S. Hershey Medical Center289 enrolled10 locationsNCT06465199
Recruiting
Phase 1

Evaluation of Xaluritamig in Adults, Adolescents and Children With Relapsed or Refractory Ewing Sarcoma (EWS)

Ewing Sarcoma
Amgen50 enrolled7 locationsNCT07297979
Recruiting
Phase 2

Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma

OsteosarcomaEwing SarcomaEwing Sarcoma Metastatic
Milton S. Hershey Medical Center406 enrolled2 locationsNCT07321912
Recruiting
Phase 1Phase 2

Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

Diffuse Large B Cell LymphomaEwing SarcomaNeuroblastoma+2 more
Merck Sharp & Dohme LLC90 enrolled70 locationsNCT06395103
Recruiting
Not Applicable

Biologically-Adapted, Dose-Escalated Radiotherapy for the Treatment of Ewing Sarcoma, BEAR Trial

Ewing SarcomaRound Cell Sarcoma With EWSR1-non-ETS Fusion
Mayo Clinic141 enrolled2 locationsNCT07188532
Recruiting
Early Phase 1

Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors

transitional cell carcinomaSoft Tissue SarcomaMelanoma+12 more
University of California, Irvine25 enrolled1 locationNCT07628634
Recruiting
Phase 1

A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid Malignancies

Advanced Solid TumorsEwing SarcomaHepatocellular Carcinoma (HCC)+1 more
SEED Therapeutics, Inc.171 enrolled6 locationsNCT07197554
Recruiting
Phase 1

Selective Antigen Specific T Cells and CAR T Cells in Subjects With Relapsed/Refractory Embryonal Tumors (SABRE)

Ewing SarcomaNeuroblastomaRhabdomyosarcoma+1 more
Children's National Research Institute18 enrolled2 locationsNCT07172958
Recruiting
Phase 1

Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas

Ewing SarcomaColorectal Adenocarcinoma
Inhibrx Biosciences, Inc411 enrolled36 locationsNCT03715933
Recruiting
Phase 1

B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)

Soft Tissue SarcomaMelanomaCarcinoma+13 more
St. Jude Children's Research Hospital48 enrolled1 locationNCT04897321
Recruiting
Phase 1Phase 2

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

Recurrent Malignant Solid NeoplasmRefractory Malignant Solid NeoplasmRecurrent Solid Tumor+19 more
St. Jude Children's Research Hospital90 enrolled10 locationsNCT04901702
Recruiting
Phase 1

Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes

Metastatic Ewing Sarcoma
H. Lee Moffitt Cancer Center and Research Institute15 enrolled17 locationsNCT07194044
Recruiting
Phase 1Phase 2

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

Ovarian CarcinomaColorectal CarcinomaMelanoma+19 more
Children's Oncology Group147 enrolled21 locationsNCT04851119
Recruiting
Phase 1Phase 2

Personalized Vaccination in Fusion+ Sarcoma Patients (PerVision)

Ewing SarcomaRhabdomyosarcomaSynovial Sarcoma
University Hospital Tuebingen30 enrolled4 locationsNCT06094101
Recruiting
Phase 1

A Study of DXC008 in Patients With Prostate Cancer and Other Solid Tumors

Prostate CancerEwing SarcomaOther Solid Tumors
Hangzhou DAC Biotechnology Co., Ltd.110 enrolled3 locationsNCT06926283
Recruiting
Not Applicable

Targeted Oligometastatic Radiation in Pediatric and Young Adult Patients With Soft Tissue and Bone Sarcoma

Metastatic SarcomaEwing SarcomaRhabdomyosarcoma+1 more
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins70 enrolled2 locationsNCT06796543
Recruiting
Phase 1

Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies

Germ Cell TumorEwing SarcomaNeuroblastoma+3 more
New York Medical College30 enrolled1 locationNCT04308330
Recruiting
Phase 1Phase 2

Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

OsteosarcomaEwing SarcomaNeuroblastoma+2 more
Milton S. Hershey Medical Center104 enrolled21 locationsNCT06541262
Recruiting
Phase 1Phase 2

Lurbinectedin in FET-Fused Tumors

Ewing SarcomaPediatric CancerDesmoplastic Small Round Cell Tumor+1 more
Children's Hospital of Philadelphia63 enrolled6 locationsNCT05918640
Recruiting

Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the Bone

ChondrosarcomaBone SarcomaChordoma+2 more
Mayo Clinic72 enrolled3 locationsNCT05033288