Identification of Brain Injury Using Portable MRI
Prospective Identification of Hypoxic Ischemic Brain Injury Using Portable Magnetic Resonance Imaging
Yale University
60 participants
Dec 2, 2025
OBSERVATIONAL
Conditions
Summary
The goal of this study is to look for brain injury in patients who had a cardiac arrest, using portable brain imaging. The portable nature of this test will also allow for serial imaging so the investigators can understand how brain injury changes over days. The results of this study may allow for bedside imaging to be available at centers without specialized imaging centers and may identify markers of brain injury that help to select the patients most likely to benefit for clinical trials.
Eligibility
Inclusion Criteria4
- Unresponsive immediately after ROSC from IHCA or OHCA
- Age ≥ 18 years of age
- Conventional MRI is clinically indicated
- Treatment with temperature control
Exclusion Criteria3
- MRI contraindication according to the American Heart Association guidelines
- Inability to tolerate supine positioning for 30 minutes
- Diffuse loss of grey-white differentiation and sulcal effacement on head computed tomography within 6 hours of ROSC
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Participants will receive 2-3 portable MRI scans: \<6 hours, 6-24 hours, and within 12 (+/- 12) hours of conventional MRI
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07197918