RecruitingNot ApplicableNCT07198594

Accelerated rTMS Therapeutic Approach for Refractory Obsessive-Compulsive Disorder

A Study on the Efficacy and Safety of Accelerated Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder and Its Underlying Neurological Mechanisms


Sponsor

Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University

Enrollment

20 participants

Start Date

Jul 3, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn if individualized accelerated repetitive transcranial magnetic stimulation (rTMS) targeting the inferior frontal cortex combined with symptom provocation works to treat obsessive-compulsive disorders (OCD) in adults. It will also learn about the safety of rTMS over right IFC. The main questions it aims to answer are: * Does rTMS using a new individualized IFC target relieve participants' OCD symptoms? * What medical problems do participants have when taking rTMS? Participants will: * Take rTMS six times per day for 5 consecutive days * Visit the clinic once at baseline, the day and four weeks after treatment for checkups and tests


Eligibility

Min Age: 18 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is testing an accelerated form of repetitive magnetic brain stimulation (rTMS) as a treatment for people with obsessive-compulsive disorder (OCD) that hasn't responded well to standard therapies like medication or therapy. The treatment uses magnetic pulses to target specific brain areas involved in OCD. **You may be eligible if...** - You are 18–60 years old and right-handed - You have been diagnosed with OCD - Your OCD symptoms are severe enough to score 16 or above on the standard OCD rating scale - You have tried at least 2 medications (SSRIs or clomipramine) at optimal doses for at least 12 weeks each, without enough improvement - Your medication has been stable for at least 4 weeks **You may NOT be eligible if...** - You have OCD associated with tics (Tourette syndrome) - You have metal implants in your head or a pacemaker - You have a history of seizures - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERrTMS

individualized rTMS target the IFC with symptom provocation


Locations(1)

Shanghai Pudong New Area Mental Health Centre

Shanghai, Shanghai Municipality, China

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NCT07198594


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