Evaluation of the Variation of the Sub-pulmonary Velocity-time Integral to Predict Fluid Responsiveness
Evaluation of the Variation of the Sub-pulmonary Velocity-time Integral to Predict Fluid Responsiveness Prospective Observational Study
Hospital Nord
205 participants
Nov 7, 2024
OBSERVATIONAL
Conditions
Summary
Fluid administration is the first-line treatment in hypovolemic states in critically ill patients. Prediction of fluid responsiveness is possible with echocardiography by assessing the variation of the sub-aortic velocity-time integral (AoVTI) during a passive leg raising test (PLR) or Mini-fluid challenge. However, VTI-Ao measurement is not feasible in all patients due to poor echogenicity. Validation of new fluid-responsiveness indices may facilitate the evaluation in this patient population. Among the available indices, variation of the sub-pulmonary VTI is a potential criterion.
Eligibility
Inclusion Criteria3
- Patient with measurable sub-pulmonary VTI in at least one of the two windows: parasternal short-axis or subcostal.
- Patient with measurable sub-aortic VTI in apical 4-chamber view before and after PLR maneuver.
- Patient with suspected hypovolemia or whose hemodynamic status justifies vasopressor infusion.
Exclusion Criteria8
- Severe left ventricular dysfunction defined by left ventricular ejection fraction (LVEF) < 30%.
- Severe right ventricular dysfunction defined by TAPSE < 12 mm.
- Cardiac arrhythmia or atrial fibrillation.
- Abdominal compartment syndrome.
- Amputation of one or both lower limbs.
- Intracranial hypertension.
- Pregnant women (ruled out by systematic pregnancy test at ICU admission).
- Minors.
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Interventions
Fluid infusion of 500 mL of a crystalloïd solution is performed for patients with signs of hypovolemia
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT07202637