RecruitingNot ApplicableNCT07206602

AI-Guided Left Bundle Branch Area Pacing

A Pilot Study Assessing Outcomes Of Artificial Intelligence-Guided Left Bundle Branch Area Pacing For Cardiac Resynchronization In Heart Failure


Sponsor

Mayo Clinic

Enrollment

224 participants

Start Date

Jan 23, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to compare the effectiveness of AI-guided LBBAP versus conventional LBBAP (not AI-guided) in improving CRT response rates and clinical outcomes.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing an AI-guided approach to a type of heart pacemaker implantation called Left Bundle Branch Area Pacing (LBBAP). Traditional pacemakers often pace from the right side of the heart, which can weaken heart function over time. LBBAP aims to pace from a more natural location to preserve heart pumping strength, and this study uses AI to help guide the procedure. **You may be eligible if...** - You are 18 or older - Your heart's pumping function is reduced (ejection fraction below 50%) based on a test in the past 6 months - Your heartbeat is too wide on an ECG (QRS duration 130 ms or more), OR your current pacemaker paces from the right ventricle more than 40% of the time, OR your heart is expected to require right ventricular pacing - You are on optimized, guideline-recommended heart failure medications - An AI-based ECG analysis suggests a high probability of reduced heart function **You may NOT be eligible if...** - You are under 18 years old - You are unable to come back for follow-up visits - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEAI-assisted Left Bundle Branch Area Pacing

Patients will undergo a Left Bundle Branch Area Pacing (LBBAP) procedure using AI assisted technology

PROCEDURELeft Bundle Branch Area Pacing

Patients will undergo a Left Bundle Branch Area Pacing (LBBAP) procedure


Locations(1)

Mayo Clinic in Rochester

Rochester, Minnesota, United States

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NCT07206602


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