RecruitingNot ApplicableNCT07206602

AI-Guided Left Bundle Branch Area Pacing

A Pilot Study Assessing Outcomes Of Artificial Intelligence-Guided Left Bundle Branch Area Pacing For Cardiac Resynchronization In Heart Failure

Sponsor

Mayo Clinic

Enrollment

224 participants

Start Date

Jan 23, 2026

Study Type

INTERVENTIONAL

Conditions

Heart Failure

Summary

The purpose of this study is to compare the effectiveness of AI-guided LBBAP versus conventional LBBAP (not AI-guided) in improving CRT response rates and clinical outcomes.

Eligibility

Min Age: 18 Years

Inclusion Criteria5

Age: 18 years or older.
Left Ventricular Ejection Fraction (LVEF): \<50% within 6 months prior to enrollment.
QRS Duration: Resting QRS duration ≥ 130 ms on ECG OR anticipated right ventricular pacing \> 40% OR device in place with right ventricular pacing \> 40% within 6 months prior to enrollment.
Medical Therapy: Optimized on guideline-directed medical therapy for heart failure.
AI-ECG probability of low LVEF: \>0.5