Identification of Early Markers for ALS
Institut National de la Santé Et de la Recherche Médicale, France
60 participants
Sep 30, 2024
INTERVENTIONAL
Conditions
Summary
Although several molecules have been proposed as biomarker candidates, a clinically established signature for an early or even premotor diagnosis of ALS is not available. Due to the already advanced, disease stage at the time of diagnosis as well as rapid disease progression, an early diagnosis is mandatory for efficacious disease-modifying therapies. In this project, the investigators will develop a clinical molecular fingerprint of PGMC that will provide insight into the molecular pathogenesis of ALS and allow earlier diagnosis.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
After information and consent by the investigator, clinical data will be collected using a CRF and biological samples (Blood sampling, Urine sample, cephalo spinal fluid), lacrimal fluid sampling, and a smell test will be taken from all subjects at baseline and at 12 months.
Locations(1)
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NCT07213440