Amyotrophic Lateral Sclerosis(ALS) Clinical Trials

34 recruitingLast updated: June 18, 2026

There are 34 actively recruiting amyotrophic lateral sclerosis(als) clinical trials across 18 countries. Studies span Not Applicable, Phase 2, Phase 1, Early Phase 1. Top locations include San Francisco, California, United States, Toronto, Ontario, Canada, Montreal, Quebec, Canada. Updated daily from ClinicalTrials.gov.


Amyotrophic Lateral Sclerosis(ALS) Trials at a Glance

34 actively recruiting trials for amyotrophic lateral sclerosis(als) are listed on ClinicalTrialsFinder across 6 cities in 18 countries. The largest study group is Not Applicable with 13 trials, with the heaviest enrollment activity in San Francisco, Toronto, and Montreal. Lead sponsors running amyotrophic lateral sclerosis(als) studies include Neuralink Corp, Duke University, and University of Pennsylvania.

Browse amyotrophic lateral sclerosis(als) trials by phase

Treatments under study

About Amyotrophic Lateral Sclerosis(ALS) Clinical Trials

Looking for clinical trials for Amyotrophic Lateral Sclerosis(ALS)? There are currently 34 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Amyotrophic Lateral Sclerosis(ALS) trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Amyotrophic Lateral Sclerosis(ALS) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 34 trials

Recruiting
Phase 2

A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)

Chronic respiratory failureNon-invasive ventilationRespiratory Insufficiency+7 more
University of Pennsylvania48 enrolled3 locationsNCT07071935
Recruiting
Phase 2

PHENOGENE-1A (Cromolyn) Treatment in Patients With Mild to Moderate ALS

Amyotrophic Lateral Sclerosis(ALS)
PhenoNet, Inc.105 enrolled20 locationsNCT07142291
Recruiting
Not Applicable

Investigating the Impact of Electrical Stimulation on Facial Pain, Jaw Movement and Oral Health in People With Motor Neuron Disease.

Amyotrophic Lateral Sclerosis(ALS)Motor Neuron Disease / Amyotrophic Lateral SclerosisPrimary Lateral Sclerosis (PLS)
Nova Southeastern University10 enrolled1 locationNCT07187388
Recruiting
Phase 1Phase 2

A Clinical Trial to Evaluate NB-4746 in Participants With Amyotrophic Lateral Sclerosis.

Amyotrophic Lateral Sclerosis(ALS)
Nura Bio80 enrolled6 locationsNCT07369076
Recruiting
Phase 2

Study of COYA 302 for the Treatment of ALS

Amyotrophic Lateral Sclerosis(ALS)
Coya Therapeutics120 enrolled25 locationsNCT07161999
Recruiting

Influence of Olfacto-gustatory Sensoriality on the Nutritional Status of Patients With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis(ALS)
Centre Hospitalier Universitaire Dijon60 enrolled1 locationNCT06608004
Recruiting
Not Applicable

Hypercaloric PEG Nutrition in ALS to Sustain Energy Homeostasis

Amyotrophic Lateral Sclerosis(ALS)
University of Ulm76 enrolled1 locationNCT06877143
Recruiting
Phase 1Phase 2

Intestinal Microbiome Transplant in ALS

Amyotrophic Lateral Sclerosis(ALS)
Duke University20 enrolled1 locationNCT07017946
Recruiting
Not Applicable

Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)

Spinal Cord Injuries (SCI)Amyotrophic Lateral Sclerosis(ALS)Muscular Dystrophies+6 more
Johns Hopkins University5 enrolled1 locationNCT07521930
Recruiting
Not Applicable

Examining Interactions Between PALS and Caregivers

Amyotrophic Lateral Sclerosis(ALS)
Penn State University152 enrolled1 locationNCT06819124
Recruiting
Phase 1Phase 2

First in Human (FIH) Study of ALN-SOD in Adult Participants With Amyotrophic Lateral Sclerosis Associated With Mutation in the SOD1 Gene (SOD1-ALS)

Amyotrophic Lateral Sclerosis(ALS)Mutation in the Superoxide Dismutase-1 (SOD1) Gene
Regeneron Pharmaceuticals42 enrolled16 locationsNCT06351592
Recruiting

Retinal Imaging in Neurodegenerative Disease

Traumatic Brain InjuryHuntington DiseaseNeuro-Degenerative Disease+12 more
Duke University2,000 enrolled1 locationNCT03233646
Recruiting
Not Applicable

Quantification of Hsp90 in the Human Brain

Amyotrophic Lateral Sclerosis(ALS)Alzheimer's Disease(AD)Parkinson's Disease (PD)
Universitaire Ziekenhuizen KU Leuven48 enrolled1 locationNCT07380204
Recruiting

Healing ALS Registry Observational Study (HAROS)

Amyotrophic Lateral Sclerosis(ALS)Motor Neuron Disease (MND)Primary Lateral Sclerosis (PLS)
Healing Advocates Registry and Ministry1,000 enrolled1 locationNCT07233148
Recruiting

UPenn Observational Research Repository on Neurodegenerative Disease

Corticobasal Syndrome(CBS)Progressive Supranuclear Palsy (PSP)Primary Progressive Aphasia(PPA)+6 more
University of Pennsylvania1,000 enrolled1 locationNCT04715399
Recruiting
Not Applicable

Lung Insufflation Capacity Training and Respiratory Function in Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis(ALS)
National Center of Neurology and Psychiatry, Japan15 enrolled1 locationNCT07257302
Recruiting

Translating Single-cell Vulnerability Into Novel ALS Biomarkers and Therapeutic Targets: Towards a Liquid Nerve Biopsy

Peripheral NeuropathiesAmyotrophic Lateral Sclerosis(ALS)
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta400 enrolled4 locationsNCT07268833
Recruiting
Phase 1

The Safety, Tolerability and Preliminary Efficacy of Derived Motor Neuron Progenitor Cells (XS228CN) in Subjects With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis(ALS)
XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.12 enrolled1 locationNCT07118319
Recruiting
Not Applicable

Identification of Early Markers for ALS

Amyotrophic Lateral Sclerosis(ALS)
Institut National de la Santé Et de la Recherche Médicale, France60 enrolled1 locationNCT07213440
Recruiting

Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging

EpilepsyMultiple SclerosisAlzheimer Disease+7 more
Assistance Publique Hopitaux De Marseille700 enrolled1 locationNCT07202494