Follicular Fluid microRNAs in Ovarian Aging and Reproduction
Investigating the Role of Follicular Fluid microRNAs in Ovarian Aging and Assisted Reproductive Success
University of Central Florida
100 participants
Sep 22, 2025
OBSERVATIONAL
Conditions
Summary
The purpose of this study is to investigate the role of exosomal microRNAs (miRNAs) in follicular fluid (FF) as biomarkers of ovarian aging and predictors of in vitro fertilization (IVF) outcomes. The goal is to identify noninvasive molecular markers that correlate with oocyte quality and reproductive potential, particularly in women of advanced maternal age.
Eligibility
Inclusion Criteria4
- Women undergoing IVF treatment due to male factor infertility or nonovarian causes.
- Age groups: younger women <31 years and older women >38 years.
- Regular menstrual cycles.
- Willing and able to provide informed consent.
Exclusion Criteria8
- Minors (under 18 years) and women aged 32-37 years
- Diagnosis of polycystic ovarian syndrome (PCOS).
- History of recurrent pregnancy loss.
- Presence of endometriosis.
- Diagnosis of ovarian insufficiency.
- Metabolic disorders (e.g., diabetes).
- History of ovarian surgery or chemotherapy.
- Any condition that might impact follicular fluid quality or IVF outcomes.
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Interventions
No interventions for participants
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07214246