A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease

This study is testing a new drug called ALN-5288 in people with Alzheimer's disease. The drug is given by injection into the spinal fluid (intrathecally) and aims to slow or modify the disease process. **You may be eligible if...** - You have a confirmed diagnosis of Alzheimer's disease, supported by spinal fluid tests or a brain scan showing amyloid plaques (within the last 7 years) - You have mild memory impairment or mild to moderate dementia due to Alzheimer's disease - Your doctor believes you are physically and mentally able to complete the study **You may NOT be eligible if...** - Your dementia is caused by something other than Alzheimer's disease - You have significantly abnormal liver or kidney function - You have uncontrolled high blood pressure, active HIV, or hepatitis B/C infection - You have a bleeding disorder or history of uncontrolled seizures in the last 6 months - You have a brain or spine condition that would make the injection procedure unsafe Talk to your doctor to see if this trial is right for you.