RecruitingNCT07215130

Selective Removal of Endometriotic Lesions Using CUSA Clarity in Ovarian Endometriomas

Selective Removal of Endometriotic Lesions Using CUSA Clarity in Ovarian Endometriomas: A Case-Based Histopathological Study

Sponsor

Kanazawa University

Enrollment

10 participants

Start Date

Jan 30, 2025

Study Type

OBSERVATIONAL

Conditions

Endometriosis Ovarian Endometrioma

Summary

This study aims to evaluate the feasibility and tissue selectivity of a novel surgical technology, the Cavitron Ultrasonic Surgical Aspirator (CUSA) Clarity, in the management of ovarian endometriomas. Ovarian endometriomas are cysts caused by endometriosis that can damage ovarian reserve when treated by conventional surgery. In this study, ovarian cyst wall specimens are examined ex vivo using different Tissue Select settings of the CUSA device. Histopathological analyses are performed to determine whether endometriotic epithelium can be selectively removed while preserving normal ovarian tissue. The findings may contribute to developing fertility-preserving surgical approaches for women with endometriomas.

Eligibility

Sex: FEMALEMin Age: 20 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a surgical device called CUSA Clarity for removing ovarian endometriomas (cysts caused by endometriosis) during surgery. Researchers want to see if it can remove endometriotic tissue more precisely while preserving healthy ovarian tissue. **You may be eligible if...** - You are a woman age 20 or older diagnosed with an ovarian endometrioma - You are scheduled for surgery (cystectomy or removal of the ovary) at Kanazawa University Hospital in Japan between January 2025 and March 2027 - You have provided written informed consent **You may NOT be eligible if...** - Your imaging suggests the cyst might be cancerous - Your doctor determines you are not suitable for participation for any medical reason Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICECavitron Ultrasonic Surgical Aspirator (CUSA) Clarity

Ex vivo application of the Cavitron Ultrasonic Surgical Aspirator (CUSA) Clarity device to ovarian endometrioma cyst wall specimens. Tissue Select settings from 0 to 4 are used to evaluate tissue selectivity, specifically removal of endometriotic epithelium while preserving normal ovarian stroma. Samples are subsequently analyzed histopathologically.

Locations(1)

Kanazawa University Hospital

Kanazawa, Ishikawa-ken, Japan

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NCT07215130

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