RecruitingPhase 2NCT07215520

Safety and Tolerability of a Newcastle Disease Virus-Based Mucosal COVID-19 Vaccine in Previously Vaccinated Adults

A Double-blind, Randomized, Controlled, Phase 2a Study to Evaluate the Safety and Tolerability of a Newcastle Disease Virus-based Mucosal Vaccine (NDV-HXP-S-KP.2) Relative to an Approved Systemic mRNA Vaccine in Previously Vaccinated Adults


Sponsor

CastleVax Inc.

Enrollment

200 participants

Start Date

Nov 3, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

A Double-blind, Randomized, Controlled, Phase 2a Study to Evaluate the Safety and Tolerability of a Newcastle Disease Virus-based Mucosal Vaccine (NDV-HXP-S-KP.2) Relative to an Approved Systemic mRNA Vaccine in Previously Vaccinated Adults


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a biological treatment called COVID-19 mRNA Vaccine and a biological treatment called NDV-HXP-S-KP.2 for people with covid-19. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALNDV-HXP-S-KP.2

Nasal Administration of a COVID-19 vaccine to compare against a commercially available mRNA vaccine

BIOLOGICALCOVID-19 mRNA Vaccine

Used as a comparator to study vaccine


Locations(2)

Skylight Health Research

Colorado Springs, Colorado, United States

Skylight Health Research

Burlington, Massachusetts, United States

View Full Details on ClinicalTrials.gov

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NCT07215520


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