Studying Off Label Insurance Coverage for Patients With Cutaneous Cancers a "Filter" Observational Study

This observational study is tracking real-world outcomes for patients with rare skin cancers — including Merkel cell carcinoma, mucosal melanoma, basal cell carcinoma, and certain squamous cell carcinomas — who receive standard immunotherapy or targeted treatments before surgery. The goal is to understand how well these treatments work and how insurance covers them. **You may be eligible if...** - You are 18 or older with a biopsy-confirmed diagnosis of one of the eligible skin cancer types - Your cancer is resectable (can be surgically removed) or may become resectable after treatment - You are scheduled to receive standard immunotherapy or targeted therapy before surgery - Genomic (genetic) testing of your cancer has been attempted **You may NOT be eligible if...** - Your cancer has spread so extensively that complete surgical removal is not possible - You have had prior treatment (immunotherapy, chemotherapy, or radiation) for this cancer - You have any medical condition that your doctor considers a contraindication to immunotherapy - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.