Novel Treatment of Radiation Associated Dysphagia With Statins

This study is testing whether a statin medication (a type of cholesterol drug commonly used for heart health) can help treat radiation-associated dysphagia — swallowing difficulties caused by radiation therapy to the head and neck. Many cancer survivors develop trouble swallowing years after radiation treatment. **You may be eligible if...** - You have had radiation therapy to the head or neck for cancer (nasopharynx, oropharynx, hypopharynx, or larynx) at least 2 years ago - You are currently experiencing moderate-to-severe swallowing problems caused by the radiation - Your swallowing difficulty was confirmed on a swallowing test (videofluoroscopic swallow study) within the last 12 months - Your kidney and liver function are adequate - You are 18 or older **You may NOT be eligible if...** - You are allergic to pravastatin or cannot take statins - You have muscle weakness (myasthenia) - You have had head or neck surgery (beyond minor biopsy or neck dissection) - You have an active cancer - You are already taking statin medication - You are taking long-term steroids or certain other prohibited medications Talk to your doctor to see if this trial is right for you.