Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)

This study is testing whether a combination of medications — including a statin (cholesterol-lowering drug) and a drug that improves blood flow — can reduce lymphedema (swelling) and tissue scarring (fibrosis) in the neck that develops after radiation therapy for head and neck cancer. **You may be eligible if...** - You previously had head and neck cancer and are now cancer-free - You received radiation to your neck (at least 30 Gy) as part of your treatment - You have grade 2 or higher lymphedema or fibrosis in the neck, occurring more than 6 months after radiation - You are male or post-menopausal - You do not have diabetes, active liver disease, or heart disease **You may NOT be eligible if...** - You are currently pregnant or pre-menopausal (and female) - You have active liver disease, cirrhosis, or alcoholism - You have a history of heart attack or severe heart disease - You have a history of muscle breakdown disorder - You are allergic to statins or caffeine-related compounds - You have diabetes Talk to your doctor to see if this trial is right for you.