A Trial to Test Intermittent Deep Brain Stimulation of Nucleus Basalis of Meynert to Treat Alzheimers.

This study is testing a type of deep brain stimulation (DBS) — a surgical procedure where a small device is implanted in the brain to deliver gentle electrical pulses — to treat early-stage Alzheimer's disease. The stimulation targets a brain area called the Nucleus Basalis of Meynert, which is important for memory and attention. **You may be eligible if...** - You are between 65 and 85 years old - You have been diagnosed with early-stage Alzheimer's disease (confirmed by a PET scan showing beta-amyloid plaques) - Your memory and thinking are mildly affected (CDR global score of 0.5 to 1.0; MMSE of 21 or higher) - Your Alzheimer's medications have been stable for at least 60 days - You live at home and have a caregiver willing to participate - You do not have significant depression, hallucinations, or agitation **You may NOT be eligible if...** - You have another form of dementia (such as Lewy Body dementia) - You have a serious brain condition such as a tumor, stroke, or head trauma within the past 2 years - You have a major psychiatric illness such as schizophrenia or bipolar disorder - You have metal implants or devices that prevent MRI scans Talk to your doctor to see if this trial is right for you.