A Research Study on the Effects of NNC0537-1482 in Participants With Heart Failure

This study is testing a new drug called NNC0537-1482 in people with heart failure with a preserved or mildly reduced pumping function (known as HFmrEF or HFpEF). In this type of heart failure, the heart pumps adequately but is too stiff, leading to symptoms like shortness of breath and fatigue. **You may be eligible if...** - You are between 40 and 75 years old (both inclusive) - You have been diagnosed with heart failure with symptoms (NYHA Class II or III — moderate symptoms) - Your heart failure medications have been stable for at least 4 weeks before the study - You are a male or a female who is not of childbearing potential - Your BMI is between 18.5 and less than 40 **You may NOT be eligible if...** - You have recently changed your heart failure medications - You are pregnant or of childbearing potential - You have severe kidney or liver problems - You have certain other serious heart conditions not consistent with HFmrEF/HFpEF Talk to your doctor to see if this trial is right for you.