A Study for Imaging the Lower Gastrointestinal Tract Using a Retro-TCE Capsule

This study is testing a new type of capsule called the Retro-TCE capsule for imaging the lower gastrointestinal (GI) tract — the colon and rectum. Instead of a traditional colonoscopy where a doctor inserts a camera, this capsule is swallowed (or administered via an enema-like approach) and travels through the bowel taking pictures. **You may be eligible if...** - You are between 18 and 75 years old - You are generally healthy OR have a confirmed diagnosis of Lynch Syndrome (a genetic condition increasing colon cancer risk) - You had a normal colonoscopy within the past 24 months OR you report no GI symptoms or known bowel problems - You are able to follow bowel preparation instructions **You may NOT be eligible if...** - You are over 75 years old - You have had colorectal cancer, diverticulosis, diverticulitis, or previous bowel surgery - You have anal or colon strictures (narrowings) - You have bleeding disorders or take blood thinners (other than low-dose aspirin) - You are pregnant - You have severe inflammatory bowel disease or large hemorrhoids Talk to your doctor to see if this trial is right for you.