RecruitingNCT07220512

The Better, Harder, Faster, Stronger Study

The BHFS Study (Better, Harder, Faster, Stronger): Does Neoadjuvant Chemotherapy Improve Fitness for Surgery?

Sponsor

Wake Forest University Health Sciences

Enrollment

35 participants

Start Date

Jul 28, 2025

Study Type

OBSERVATIONAL

Conditions

Ovarian Cancer Endometrial Cancer Neoadjuvant Chemotherapy Cognitive Dysfunction Frailty at Older Adults

Summary

The purpose of this study is to evaluate changes in the electronic Frailty Index (eFI) score following 3-4 cycles of neoadjuvant chemotherapy (NACT) in participants with advanced ovarian and endometrial cancer.

Eligibility

Sex: FEMALEMin Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study — nicknamed the "Better, Harder, Faster, Stronger" study — is testing whether exercise and nutritional support during chemotherapy (given before surgery) can improve outcomes for women with advanced ovarian or uterine cancer. **You may be eligible if...** - You are 55 years or older - You have been newly diagnosed with advanced (Stage II-IV) ovarian, fallopian tube, peritoneal, or endometrial cancer - Your treatment plan includes 3 or 4 rounds of chemotherapy before surgery - You are able to read and write in English - You are able to follow the study procedures for its full length **You may NOT be eligible if...** - You have cancer that has spread to the brain - You have certain other medical conditions that the study team determines make participation unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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