RecruitingNCT07220512

The Better, Harder, Faster, Stronger Study

The BHFS Study (Better, Harder, Faster, Stronger): Does Neoadjuvant Chemotherapy Improve Fitness for Surgery?

Sponsor

Wake Forest University Health Sciences

Enrollment

35 participants

Start Date

Jul 28, 2025

Study Type

OBSERVATIONAL

Conditions

Ovarian Cancer Endometrial Cancer Neoadjuvant Chemotherapy Cognitive Dysfunction Frailty at Older Adults

Summary

The purpose of this study is to evaluate changes in the electronic Frailty Index (eFI) score following 3-4 cycles of neoadjuvant chemotherapy (NACT) in participants with advanced ovarian and endometrial cancer.

Eligibility

Sex: FEMALEMin Age: 55 Years

Inclusion Criteria6

Ability to understand and willingness to sign an IRB-approved informed consent.
Age \> 55 years at the time of enrollment.
Newly diagnosed suspected ovarian/primary peritoneal/fallopian tube carcinoma of any histological subtype, FIGO Stage II-IV, per enrolling investigator, or newly diagnosed suspected endometrial carcinoma of any histologic subtype, FIGO Stage II-IV, per enrolling investigator.
Planned for 3 or 4 cycles of NACT, with interval cytoreductive surgery planned thereafter.
Ability to read, understand, and write the English language.
As determined by the enrolling investigator, ability of the participant to understand and comply with study procedures for the entire length of the study.

Exclusion Criteria4

History of brain metastases.
History of poorly controlled psychiatric conditions, defined as hospitalization within the prior 3 months for psychiatric disorders, traumatic brain injury, cerebrovascular event, or dementia, per the enrolling investigator.
Use of anti-amyloid agents, cholinesterase inhibitors, or glutamate regulators at the time of enrollment.
Vision impairment that would impede completion of study assessments, per enrolling investigator.