RecruitingNot ApplicableNCT07220525

Disrupted Sleep and Concurrent Ectopy or Atrial Fibrillation

Sponsor

University of California, San Francisco

Enrollment

100 participants

Start Date

Dec 15, 2025

Study Type

INTERVENTIONAL

Conditions

Obstructive Sleep Apnea Atrial Fibrillation (AF)Premature Ventricular Contraction (PVC)Premature Atrial Contraction

Summary

Whereas the available evidence mostly supports chronic sleep disruption as a risk factor for incident AF, less is known about the near-term risk of a discrete atrial fibrillation (AF) episode following a night of disrupted or poor-quality sleep. This prospective, randomized, case-crossover study aims to examine the acute effects of sleep disruption on clinically relevant cardiac ectopy pertinent to AF.

Eligibility

Min Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This study is examining whether sleep disruption — caused by temporarily pausing an implanted tongue stimulator device used for sleep apnea — can trigger irregular heartbeats (like extra beats or atrial fibrillation). It aims to understand the heart-sleep connection better. **You may be eligible if...** - You are 21 or older - You have an implanted upper airway stimulation device (a device placed in your chest/neck to treat sleep apnea) managed at UCSF Health - You are willing to turn off the device for up to two days during the 14-day study period as instructed **You may NOT be eligible if...** - You are pregnant or trying to become pregnant - You are currently taking class 1 or 3 anti-arrhythmic heart rhythm medications - You have permanent atrial fibrillation - You have congenital heart disease - Your heart pacing is very high (over 40%) - You cannot read or sign consent forms Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEHGNS Use Randomized Instructions

In this intervention assignment, participants will be instructed to turn off/not use their HGNS device during that night of sleep. HGNS 'on': In this intervention assignment, participants will be instructed to turn on/use their HGNS device during that night of sleep.