A Study of Antibiotic Delivery to Prevent Infection After Breast Tissue Expander Placement

This study is testing whether placing antibiotic-releasing beads inside the breast during reconstructive surgery (after mastectomy) can reduce the risk of post-surgery infections, which are a common and serious complication. **You may be eligible if...** - You are a woman, 18 or older, scheduled for mastectomy with immediate breast reconstruction using a tissue expander - Mastectomy is planned for breast cancer treatment, prevention, or due to high genetic risk - Your BMI is under 40 - You have not smoked or used nicotine products for at least 6 weeks before surgery - You have no known allergy to calcium sulfate, vancomycin, or gentamicin (antibiotic ingredients in the beads) **You may NOT be eligible if...** - You have high blood calcium, severe vascular or nerve disease, uncontrolled diabetes, or severe bone disease - You are pregnant - You have impaired decision-making ability Talk to your doctor to see if this trial is right for you.