Hippocampal Oscillations During Exploration
Human Hippocampal Oscillations During Visuomotor Exploration
NYU Langone Health
56 participants
Feb 25, 2026
INTERVENTIONAL
Conditions
Summary
The objective of this study is to determine how visuomotor exploration relates to hippocampal activity along its long axis. The study will investigate the neurophysiological mechanisms in the hippocampus during (1) visual exploration in surgical patients using high-resolution iEEG, and (2) ambulatory exploration in patients implanted with RNS devices.
Eligibility
Inclusion Criteria10
- All subjects:
- Adults (18-70 years)
- Able to provide informed consent
- Implanted hippocampal depth electrodes for Stage 1 epilepsy surgery
- IQ=>80*
- Implanted RNS device with at least one hippocampal depth electrode
- At least 5 months post-implantation to avoid the post-implant effect
- Have a relatively low number of seizures, defined as =<1 debilitating seizure per week
- Able to walk and wear research equipment without assistance
- IQ>=80
Exclusion Criteria7
- RNS patients, Aim 2:
- Any generalized tonic-clonic seizure(s) within the last year
- All subjects:
- Legally blind
- Smoking tobacco, marijuana, recreational drugs or alcohol use within 1 week of cognitive testing
- Unable to give informed consent
- Pregnancy
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Interventions
Cognitive testing while admitted to the epilepsy monitoring unit (number of sessions will vary depending on patient availability and stamina).
Series of cognitive tasks completed during a study visit.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07224191