Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea
Stephanie B. Seminara, MD
20 participants
Dec 9, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this study is to see whether kisspeptin, a naturally occurring hormone, can stimulate the release of other reproductive hormones in women with hypothalamic amenorrhea (HA). The investigators are also examining whether kisspeptin can help women release eggs from their ovaries. Kisspeptin will be administered subcutaneously (SC) for two weeks in a pulsatile fashion. Ultrasound monitoring of ovarian follicular growth and frequent blood sampling (every 10 minutes for up to two hours) will be performed to assess the physiologic response to kisspeptin over time.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
SC administration of kisspeptin for two weeks (pulsatile, approximately every 90 minutes)
Locations(1)
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NCT07224438