Recovery of Physical Function After Critical Illness In Older Adults
RETURN: Recovery of Physical Function After Critical Illness In Older Adults
University of Kentucky
150 participants
Mar 11, 2026
OBSERVATIONAL
Conditions
Summary
The proposed study is a prospective, observational study assessing the recovery of muscle and physical function in patients surviving critical illness (n =150) at hospital discharge (baseline) and repeated serially. Patients will be enrolled after life-saving modalities have been weaned near hospital discharge. Patients will participate in testing at baseline, 3-, 6-, 12-, and 24-months after hospital discharge. In a subset of patients (n = 18), muscle biopsies will be performed at baseline and then repeated once at either 12- or 24-months after hospital discharge.
Eligibility
Inclusion Criteria3
- adult patients (≥40 years of age)
- patients who have survived an ICU admission of at least 72 hours
- diagnosis of acute lung injury or sepsis are eligible.
Exclusion Criteria4
- individuals who were not ambulatory prior to ICU admission,
- not expected to survive at least 6 months,
- have a new or pre-existing brain infarct, injury, or neurological condition with deficits preventing participation in physical testing,
- have a pre-existing geriatric syndrome that were confound recovery trajectory
Interested in this trial?
Get notified about updates and connect with the research team.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07225257