Methadone in TKA for Post-op Pain and Opioid Reduction
Reduction of Post-op Pain and Opioid Consumption With the Addition of Methadone in Total Knee Arthroplasty: a Double-blind Randomized Control Trial
Medical University of South Carolina
162 participants
Jan 8, 2026
INTERVENTIONAL
Conditions
Summary
This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.
Eligibility
Inclusion Criteria2
- Ages 18-75 years of age
- Undergoing elective primary total knee arthroplasty with mepivacaine in the spinal anesthesia
Exclusion Criteria7
- Allergy to methadone or mepivacaine
- Severe liver disease defined as Child's Pugh Class C
- End stage renal disease requiring dialysis
- Known diagnosis of prolonged QT syndrome
- Currently pregnant
- Unable to provide written, informed consent
- Non-English speaking
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Interventions
Patients will intraoperatively be administered methadone 0.15mg/kg IV, based on ideal body weight.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07226076