Methadone in TKA for Post-op Pain and Opioid Reduction
Reduction of Post-op Pain and Opioid Consumption With the Addition of Methadone in Total Knee Arthroplasty: a Double-blind Randomized Control Trial
Medical University of South Carolina
162 participants
Jan 8, 2026
INTERVENTIONAL
Conditions
Summary
This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
Patients will intraoperatively be administered methadone 0.15mg/kg IV, based on ideal body weight.
Locations(1)
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NCT07226076