Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)

This study (called BIGSHOT) compares two radiation techniques — giving radiation in a few larger doses (hypofractionated SRS) — for treating larger brain metastases (cancer that has spread to the brain) that are between 2 and 5 centimeters in size. **You may be eligible if...** - You are 18 or older with confirmed brain metastases between 2 and 5 cm in size - You have a known or active primary cancer elsewhere in the body (diagnosed in the past 3 years) - Your general health is good enough to tolerate stereotactic radiosurgery (SRS) - Your brain symptoms are stable and do not require immediate surgery - Up to 10 additional smaller brain metastases are allowed **You may NOT be eligible if...** - Your brain tumors are smaller than 2 cm or larger than 5 cm - Your tumors are within 5 mm of the optic nerves or optic chiasm - You are unable to tolerate SRS or are neurologically unstable - You are pregnant (a negative pregnancy test is required) Talk to your doctor to see if this trial is right for you.