RecruitingPhase 1NCT07232524

A Study of BL-M24D1 in Patients With Locally Advanced or Metastatic Head and Neck Squamous Cell Carcinoma and Other Solid Tumors

A Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetic Characteristics and Preliminary Efficacy of BL-M24D1 for Injection in Patients With Locally Advanced or Metastatic Head and Neck Squamous Cell Carcinoma and Other Solid Tumors


Sponsor

Sichuan Baili Pharmaceutical Co., Ltd.

Enrollment

16 participants

Start Date

Dec 10, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study is an open, multicenter, non-randomized Phase I clinical trial to evaluate the safety, tolerability, pharmacokinetic characteristics, and preliminary efficacy of BL-M24D1 in patients with locally advanced or metastatic head and neck squamous cell carcinoma and other solid tumors.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new drug called BL-M24D1 in people with advanced head and neck squamous cell carcinoma (a type of cancer affecting the mouth, throat, or surrounding areas) or other solid tumors that have stopped responding to standard treatments. **You may be eligible if...** - You are 18 years or older (up to 75 for early phase) - You have locally advanced or metastatic head and neck squamous cell carcinoma or another solid tumor - You have at least one measurable tumor - Standard treatments have failed or you cannot tolerate them - Your heart, kidneys, liver, and blood counts are within acceptable ranges - You are generally in good health (ECOG score 0 or 1) **You may NOT be eligible if...** - You have active, uncontrolled brain metastases - You have severe heart problems - You are pregnant or breastfeeding - You have had recent major surgery or severe infections - You are on certain medications that may interact with the study drug Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGBL-M24D1

Administration by intravenous infusion for a cycle of 2 weeks.


Locations(1)

West China Hospital of Sichuan University

Chengdu, Sichuan, China

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07232524


Related Trials