Impact of UFPs and MNPs on Fetal Health
UPRISE Unravelling Ultrafine Particulate Matter and Micro Nano Plastic's Mechanisms of Impact on Fetal Health
Instituto de Investigacion Sanitaria La Fe
1,600 participants
Jan 1, 2026
OBSERVATIONAL
Conditions
Summary
This project aims at unravelling mechanisms by which exposure to air pollution (in particular Ultrafine Particulate (UFP, PM0.1), and micro nano plastic's) interferes with the normal foetus development, with a short-term causal effect in higher likeliness of preterm delivery which, in consequence, precondition a higher likeliness to suffer non-communicable diseases (NCD) later in the life.
Eligibility
Inclusion Criteria5
- Agreement to sign the informed consent;
- Non-smoking mothers and no exposure to environmental (second-hand) smoke (smoking influences UFP measurements);
- ≥18 years old (mothers have to place sensors, mothers with childhood pregnancies may live at their parental home);
- Not expecting to terminate the pregnancy (no measurements of the child);
- Having resided in the geographical area of research for a minimum period of 1 year (to be eligible for modeling exposures).
Exclusion Criteria4
- First visit after 11 weeks of gestation (to ensure 2-week monitoring in the first trimester);
- Pregnancy complications that limit exposure measurements in urine (because it may cause polyuria, for example, gestational diabetes);
- Known kidney disease (might influence exposure measurements in urine);
- Multiple pregnancy (twin or more pregnancies may have a higher risk for complications or preterm birth, no measurements in the last trimester).
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Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07238608