Dapagliflozin in Depression

This study is testing whether a medication called dapagliflozin — normally used to treat diabetes — can also help people with depression. Researchers believe it may reduce inflammation in the body and brain, which could improve mood. **You may be eligible if...** - You are 18 years or older (any gender) - You have been depressed for at least 2 months, with a moderate-to-severe score on a depression rating scale - You have a negative pregnancy test and are using effective contraception (if applicable) **You may NOT be eligible if...** - You have bipolar disorder, a personality disorder, or an eating disorder - You have a history of substance or alcohol addiction - You have a history of seizures or have received electroconvulsive therapy (ECT) - You have an inflammatory condition - You have diabetes - You have severe kidney disease - You are pregnant or breastfeeding - You have an allergy or contraindication to the study medication Talk to your doctor to see if this trial is right for you.